锰神经毒作用机理及其生物标志物研究

Studies on Mechanism and Biomarkers of Manganese Neurotoxicity

锰主要侵害基底神经节 ,选择性损伤多巴胺能神经元 ,其机制可能与神经细胞内自由基的产生、线粒体功能受损及钙稳态失调等有关。长期接触低浓度锰可能对工人神经系统产生有害的影响 。

Manganese mainly damages the basal ganglia and selectively makes dopami nergic dysfunction and neuronal loss.Its mechanism may be associated with free r adical generation, mitochondrial dysfunction and calcium homeostasis inbalance i n neurocytes and so on. Because long-term exposure to low-concentration mangan es e may have adverse effects on nervous system of worker,detecting early relevant biomarkers in peripheral tissues plays an important role in prevention and treat ment of manganese neurotoxicity.