小剂量米非司酮在子宫肌瘤术前应用的疗效观察

An Observation of Treatment of Uterine Leiomyoam with Low Does Mifepristone before the Operation

目的 :观察术前使用小剂量米非司酮治疗子宫肌瘤的疗效。方法 :选择子宫肌瘤伴贫血、拟行全子宫切除患者 2 0例 ,采用米非司酮 10mg/d ,连续服用 3个月 ;同时选用同期在年龄、临床症状及体征上无差异的未用米非司酮治疗的 2 0例子宫肌瘤患者作为对照。记录服药组用药前后临床症状、子宫及肌瘤体积 ;对服药组及对照组治疗情况和手术情况进行比较。结果 :服药组治疗期间均闭经 ,贫血较前纠正 ,子宫及肌瘤缩小 ;手术时间、术中出血及术前及术中输血率均明显减少 (P <0 0 1)。结论 :小剂量米非司酮在子宫肌瘤术前应用安全、有效 ,值得推广。

Objective:To study the results in treating uterine leiomyoma with low dose mifepristone before the operation. Methods: 40 patients with uterine leiomyoma accompanied with anemia were divided into two groups. The mifepristone group (20 patients) was treated by mifepristone 10mg/d for 3 months, and then was operated. Control group (20 patients) was done elective operation. Results: Amenorrhea was induced in all patients of mifepristone group and all signs of anemia were corrected. The volume of uterus and leiomyoma decreased after 3 months compared to pretreatment. There were significant differences . Operative time was shorter and bleeding infraoperative and the rate of transfused blood were less than that of control group(P<0.01). Conclusion: Low dose mifepristone is well tolerated, safe and effective. To treat uterine leiomyoma with low dose mifepristone before the operation is worthing spreading.