肌钙蛋白I对不稳定型心绞痛患者近期预后判断的价值

Prognostic value of serum cardiac troponin I in unstable angina pectoris

目的 评价血清肌钙蛋白I(cTnI)定量检测对不稳定型心绞痛患者 (UAP)近期预后判断的价值。方法 用化学发光酶联免疫仪对 6 2例UAP患者 ,30例健康人分别进行了血清cTnI、肌酸磷酸激酶 (CK)及肌酸磷酸激酶同功酶 (CK MB)的检测 ,并观察UAP患者住院期间的心脏事件发生率。结果 6 2例UPA患者中有 2 3例 (37.1 % )血清cTnI呈阳性 (cTnI>0 .1 μg/L) ,39例血清cTnI呈阴性 (cTnI<0 .1 μg/L) ,两组CK、CK MB水平差异无统计学意义。UAP患者cTnI阳性组 30天内发生急性心肌梗死、心源性死亡、顽固性心绞痛明显高于cTnI阴性组。结论 cTnI是反映心肌细胞损伤的高灵敏、高特异生化指标 ,cTnI水平的升高对判断不稳定型心绞痛患者近期预后有较好的预测价值。

Objective To evaluate the prognostic value of serum troponin I (cTnI) in unstable angina pectoris (UAP). Methods Serum cTnI, creatine kinase (CK), creatine kinase isoenzyme MB (CK MB) were simultaneously measured in 30 healthy subjects and 62 UAP patients with chemiluminescent enzyme immunometric assay, cardiac events were observed closely in hospital. Results Among 37.1 % of the UAP patients cTnI levels were positive (cTnI> 0.1 μg/L), 39 cases were negative, no significant difference was found in serum CK and CK MB among all the groups. Among the 62 UAP patients, the incidences of cardiac events, including acute myocardial infarction(AMI), sudden cardiac death and refractory angina pectoris within 30 days, were significantly higher in group positive than in group negative. Conclusion Serum cTnI demonstrates minor myocardial damage and can predict the prognosis of patients with unstable agina.