颞下颌关节紊乱综合征关节液白细胞介素1活性及其临床意义

INTERLEUKIN-1 ACTIVITY IN SYNOVIAL FLUIDS OF TEMPOROMANDIBULAR JOINT DISTURBANCE SYNDROME

采用传代淋巴细胞株LBRM33-IA 5和HT-2,检测了36例颞下颌关节紊乱综合征(TMJDS)关节液中IL-1活性,发现TMJDS关节液中检测到IL-1活性,且器质性改变类患者关节液IL-1活性明显高于肌肉功能紊乱类及结构紊乱类。结果提示,IL-1参与了TMJDS关节组织的病理破坏过程。

Using murine T cell close LBRM33-IA5 and HT-2, interleukin 1 (IL-1) biological activity insynovial fluids of the patients with Temporomandibular Joint Disturbance Syndrome (TMJDS) wastested. The results demonstrate that IL-1 activity is much higher in the cases with TMJ degenerativechanges than the cases with Masticatory Muscle Disorder and the cases with TMJ Disc Displacement.The findings suggest that IL-1 and IL-1 inhibitors present in synovial fluids of TMJDS, and contributeto joint destruction.