小儿乙型病毒性肝炎肝内HBV抗原特点与临床

The Characteristics of Intrahepatic HBV Antigens in Children with Hepatitis B and their Clinical Features

用ABC法对小儿乙型肝炎肝组织标本113份进行乙型肝炎病毒(HBV)抗原检测,检出率乙肝表面抗原(HBsAg)82.9%、乙肝核心抗原(HBcAg)77.3%、前S_1蛋白(PreS_1)80.0%前S_2蛋白(PreS_2)87.9%。重型肝炎HBgAg及HBcAg检出率显著低于其它各型(P<0.025)。分布形态HBsAg弥漫型>包涵体型>膜型>周边型,HBcAg核型略多于浆型。讨论了HBV抗原检出率、分布特点与临床及PreS意义。

The HBV antigens in 113 liver samples from children with hepatitis B were detected by ABC method. Among them the detected rates were: HBsAg 82.9%, HBcAg 77.3%, Pre S_1 80.8% and Pre S_2 87.9%. In severe hepatitis the detected rates of both HBsAg and HBcAg were significantly lower (P<0.025) than those of the other types. The Distribution of various patterns of HBcAg were diffuse>inclusion body like>membraneous>peripheral, and nuclear patterns of HBcAg were slightly more than that of cytoplasmic. The detected rates, characteristics of distri bution and clinical features of HBV antigens and the correlations and significance of Pre S are discussed.