289例中晚期肿瘤病人外周血T淋巴细胞表型分析

Immunophenotype Analysis of Blood T Lymphocytes in 289 Patients with Advanced Malignant Tumor

目的 :分析中晚期肿瘤病人外周血T淋巴细胞亚群测定值的特点 ,探讨其影响因素及临床意义。方法 :采用流式细胞术检测 2 89例中晚期肿瘤病人外周血T淋巴细胞亚群水平。结果 :2 89例中晚期肿瘤病人外周血T淋巴细胞亚群测得值分别为CD3+ 细胞 5 9 0 7± 14 2 8,CD4 + 2 4 70± 10 70 ,CD8+ 33 4 5± 12 72 ,CD4 /CD80 89± 0 5 6。除性别对CD3表达的影响具有统计学意义外 (P =0 0 0 3) ,其余指标不受患者性别及年龄的影响 (P >0 0 5 )。结论 :中晚期肿瘤患者普遍存在T淋巴细胞介导的细胞免疫功能下降。

Objective:To analyze the character,influence factors and clinical value of T lymphocyte subgroups in peripheral blood of patients with advanced malignant tumor.Methods:T lymphocyte subgroups in peripheral blood of 289 patients with advanced malignant tumor were detected by flow cytometry.Results:1)CD3 +T lymphocyte 59.07±14.28,CD4 +T lymphocyte 24.70±10.70,CD8 +T lymphocyte 33.45±12.72,CD4/CD8 0.89±0.56;2)The age and gender didn's influence the value of cluster of differentiation(P>0.05)except CD3 which was influenced by gender of patients(P=0.003).Conclusion:The function of cellular immunity is abnormal in patients with advanced malignant tumor.