1[1]Zhang Y,Proceca R,Maffei M,et al.Positional coloning of the mouse obese gene and it's human homogue[J].Nature,1994,372(6505):425-432.
2[2]Campfield LA,Smith FJ,Burn P,et al.The OB protein(leptin)pathway--a link between adipose tissue mass and central neural networks[J].Hormone & Metabolic Research,1996,28(12):619-32.
3[3]Pelleymounter MA,Cullen MJ,Baker MB,et al.Effects of the obese gene product on body weight regulation in ob/ob mice[J].Science 1995,269(5223):540-3.
4[4]Mikhail A A,Beck E X,Shafer A,et al.Leptin stimulates fetal and adult erythroid and myeloid development[J].Blood,1997,89(5):1507-12.
6[6]Tian Z,Sun R,Wei H,et al.Impaired natural killer(NK)cell activity in leptin receptor deficient mice:lept in as a critical regulator in NK cell development and activation[J].Biochem Biophys Res Commun,2002,298(3):297-302.
6Lord GM,Matarese G,Howard JK,et al.Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression[J].Nature,1998,394:897-901.
7Sarraf P,Frederich RC,Turner EM,et al.Multiple cytokines and acute inflammation raise mouse leptin level potential role in inflammatory anorexia[J].J Exp Med,1997,185:171-175.
8Takahashi N,Waelput W,Guisez Y.Leptin is an endogenous protective protein against the toxicity exerted by tumor necrosis factor[J].J Exp Med,1999,189:207-212.
9Zhang Y,Proenca R,Maffei M,et al.Postitonal cloning of the mouse obese gene and its human homologo[J].Nature,1994,374:479.
