期刊文献+

胃肠道间质瘤的诊断和治疗 被引量:2

Diagnosis and Treatment of Gastrointestinal Stromal Tumors
下载PDF
导出
摘要 目的 :探讨胃肠道间质瘤 (GastrointestinalStromalTumors ,GISTs)的诊断和治疗。方法 :回顾分析我院自 1999年 11月至 2 0 0 3年 5月收治的GISTs患者的病历资料。结果 :本组 39例GISTs患者 ,其中恶性 15例 ,低恶性 2 4例。肿瘤发生部位分别为 :胃 18例 ,小肠 9例 ,直肠 3例 ,其他部位 10例。 39例患者中 2例因复发伴腹腔广泛转移未手术 ;37例行手术治疗 ,其中手术切除 34例 ,姑息性切除 3例。结论 :GISTs术前诊断困难 ,手术切除是治疗GIST的主要手段。 Objective:To study the diagnosis and treatment of Gastrointestinal Stromal Tumors(GISTs).Methods:The medical data on the 39 cases with GISTs treated in our hospital from November 1999 to May 2003 were carefully analyzed retrospectively.Results:The tumors in 15 of the 39 cases were malignant while those in the other 24 cases were of low malignancy.The tumor in 18 cases occurred in the stomach;9 in the small bowel;3 in the rectal colon and 10 cases were found in the other parts of the intraperitoneal cavity.Among the 39 cases,37 had surgical operations,and 2 received nonsurgical treatment.The tumors in 34 of the 37 cases who had the surgical operations were totally removed and the tumors in the other 3 were partly removed.Conclusions:The diagnosis of GISTs was often difficult to make before operation,and a surgical operation was the main method to manage GISTs.
出处 《华西医学》 CAS 2004年第2期212-213,共2页 West China Medical Journal
关键词 胃肠道间质瘤 诊断 治疗 手术疗法 切除术 GISTs Diagnosis Treatment
  • 相关文献

参考文献6

  • 1成元华,杨光华,郭立新.77例胃肠道间质肿瘤的病理形态学及免疫组化研究[J].临床与实验病理学杂志,2001,17(2):123-127. 被引量:27
  • 2夏云宝,吴铭,刘光彦,潘功茂,奚孔明,赵海滨,吴耀义.胃肠道间质瘤影像诊断——附12例分析[J].中国医学影像技术,2002,18(1):78-79. 被引量:24
  • 3Ng EH,Pollock RE,Munsell MF,et al.Prognostic factor influencing survival in gastrointestinal leiomyosacomas.Implications for surgical management and staging[J].Ann Surg 1992;325.
  • 4Tuveson DA,Willis NA,Jacks T,et al.ST1571 inactivation of the gastrointestinal stromal tumor c-KIT oncoprotein:biological and clinical implication[J].Oncogene 2001;20:5054.
  • 5Demetri GD,vonMehren M,Blanke CD,et al.Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumor[J].N Engl J Med.2002 Aug 15;347(7):462.
  • 6王奇璐.胃癌诊断治疗学[M].中国协和医科大学出版社,2002年7月第一版.197.

二级参考文献14

  • 1[1]Mazur MT, Clark HB. Gastric stromal tumors: reappraisal of histogenesis. Am J Surg Pathol,1983;7: 507~19
  • 2[2]Kindblom LG, Remotti HE, Aldenborg F et al. Gastrointestinal pacemaker cell tumor (GIPACT) : gastrointestinal stromal tumors show phenotypic characteristics of the interstitial cells of Cajal. Am J Pathol, 1998;152:1259~69
  • 3[3]Franquemont DW. Differentiation and risk assessment of gastrointestinal stromal tumors. Am J Clin Pathol, 1995;103:41~7
  • 4[4]Sarlomo-Rikala M, Kovatich A, Barusevicius A et al. CD117: a sensitive marker for gastrointestinal stromal tumors that is more specific than CD34. Mod Pathol, 1998; 11: 728~34
  • 5[5]Sircar K, Hewlett BR, Huizinga JD et al. Interstitial cells of Cajal as precursors of gastrointestinal stromal tumors. Am J Surg Pathol, 1999; 23: 377~89
  • 6[6]Lecoin L, Gabella G, Le Douarin N. Origin of the c-kit positive interstitial cells in the avian bowel. Development, 1996;122: 725~33
  • 7[7]Young HM, Ciampoli D, Southwell BR et al. Origin of interstitial cells of Cajal in the mouse intestine. Dev Biol, 1996;180: 97~107
  • 8[8]Hirota S, Isozaki K, Moriyama Y et al. Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors. Science, 1998; 279: 577~80
  • 9[9]Matsuda R, Takahashi T, Nakamura S et al. Expression of the c-kit protein in human solid tumors and in corresponding fetal and adult normal tissues. Am J Pathol, 1993; 142: 339~46
  • 10[10]Arber DA, Tamayo R, Weiss LM. Paraffin section detection of the c-kit gene product (CD117) in human tissues: value in the diagnosis of mast cell disorders. Hum Pathol, 1998; 29: 498~504

共引文献49

同被引文献5

引证文献2

二级引证文献2

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部