胃肠道肿瘤合并疾病的治疗用药对化疗药物敏感性的影响

Effect of drug treatment of disease accompanied by gastrointestinal tumors on sensitivity of chemotherapeutic drugs

目的 探讨胃肠道肿瘤合并疾病的院前治疗用药对肿瘤化疗药物敏感性的影响。方法 回顾性分析合并高血压病 /冠心病、糖尿病、糖尿病及高血压病 /冠心病患者 79例 ,胃肠道肿瘤新鲜标本的化疗药物敏感性检测结果。院前接受心血管病或糖尿病药物治疗患者 39例 ,将各合并疾病的胃肠道肿瘤患者分别分为治疗组和未治组 ,从而计算出各组化疗药物的敏感率。结果 合并高血压病或冠心病的肿瘤患者院前接受心血管药物治疗组与未治组间比较 ,肿瘤细胞对各化疗药物的敏感性差异均有统计学意义 (P <0 .0 5 ) ;合并糖尿病及高血压病或冠心病的肿瘤患者院前接受心血管药物及糖尿病药物治疗组与未治组间比较 ,肿瘤细胞对各化疗药物的敏感性差异均有统计学意义 (P<0 .0 5 ) ;合并糖尿病的肿瘤患者院前接受糖尿病治疗组与未治组间比较 ,肿瘤细胞对各化疗药物的敏感性差异均无统计学意义 (P >0 .0 5 )。结论 胃肠道肿瘤合并高血压病或冠心病的患者院前治疗用药对肿瘤化疗药物敏感性有影响 ;

Objective To discuss effect of drug treatment of disease accompanied by gastrointestinal tumors on sensitivity of chemotherapeutic drugs.Methods The results of sensitivity measuring of chemotherapeutic drugs were analyzed retrospectively on survival tumor specimens of 79 patients with gastrointestinal tumors accompanied by hyperpiesia,coronary heart disease,or diabetes mellitus,hyperpiesia or coronary heart disease and diabetes.Among of these patients,39 patients had received pre admission corresponding drug treatment.All patients were divided into two groups(treatment group and treatment free group).To figure out sensitivity rate of every group.Results For patients with gastrointestinal tumors accompanied by hyperpiesia,or coronary heart disease,or hyperpiesia or coronary heart disease and diabetes,the difference in sensitivity of chemotherapeutic drugs between treatment group and treatment free group reached statistical significance.By contrast,for patients with gastrointestinal tumors accompanied by diabetes mellitus,the difference in sensitivity of chemotherapeutic drugs between two groups didn′t reach statistical significance.Conclusions Pre admission corresponding drug treatment might have a significant effect on sensitivity of chemotherapeutic drugs in patients with gastrointestinal tumors accompanied by hyperpiesia,or coronary heart disease,but for patients with gastrointestinal tumors accompanied by diabetes mellitus,the effect didn′t reach statistical significance.