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14-3-3蛋白在神经退行性变疾病诊断中的应用

The diagnostic value of 14-3-3 protein in neurodegeneration diseases
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摘要 14 3 3蛋白是分布十分广泛的真核生物蛋白质 ,在脑组织中含量丰富。哺乳动物中 ,1 4 3 3蛋白主要包括 7个亚型 ,在体内发挥诸多重要的生物学功能。目前 ,1 4 3 3蛋白检测主要用于对克 雅病 (CJD)的辅助诊断。 1 4 3 3蛋白也可在一些其他的神经系统退行性变疾病中检出 ,如某些病毒性脑炎、急性脑梗塞、中风等。随着针对 1 4 3 3蛋白各亚型抗体的制备以及 1 4 3 3蛋白检测技术的改进 ,为神经退行性变疾病之间的鉴别诊断提供了可能 ,同时也为进一步研究 1 4 3
出处 《国外医学(临床生物化学与检验学分册)》 2004年第3期226-228,共3页 Foreign Medical Sciences(section of Clinical Biochemistry and Laboratory Medicine
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