全身炎症反应综合征患者血浆中D—二聚体变化的意义

The change of D-dimer concentration in plasma from the patients with SIRS

目的 观察合并全身炎症反应综合征的危重病患者凝血功能紊乱情况 ,探讨凝血功能紊乱在全身炎症反应综合征 (SIRS)中的作用及其与SIRS病情严重程度的关系。方法 随机选择 3 0例合并SIRS的危重病患者 ,在患者入ICU后次日采用免疫比浊法进行血浆D -二聚体定量检测 ;根据患者的预后不同 ,将患者分为死亡组 ( 13例 )和存活组 ( 17例 ) ;同期在我院外科住院的非SIRS患者 2 9例为对照组。结果 SIRS组与对照组比较 ,D -二聚体含量明显升高 (P <0 .0 0 1) ;死亡D -二聚体含量明显高于存活组 (P <0 .0 5 )。结论 SIRS患者存在凝血纤溶系统功能紊乱 。

Objective To investigate the coagulation disorder in the critical patients with SIRS and discuss its role in SIRS and its relation to severity of diseases.Methods 30 patients were divided into two groups according to their prognosis:death group( n =13)and survivor group( n =17).Meanwhile,29 patients of controls were chosen.D-dimer was measured by immune turbidimetry.Results The level of D-dimer in SIRS group was significantly higher than that of controls ( P <0.001).The level of D-dimer of death patients was higher than that of survivor in SIRS group ( P <0.05).Conclusion Critical patients with SIRS have abnormality in coagulation and fibrinolysis.It played an important role in the development of MODS and the death of critical patients.