新生儿高未结合胆红素血症心肌酶检测的临床意义

Clinical value of myocardial enzymes evaluation in neonates unconjugated hyperbilirubinemia

目的 :探讨新生儿高未结合胆红素血症心肌酶变化及临床意义。方法 :分别于入院时(治疗前 )和治疗后 (显性黄疸消退后 ) ,抽不抗凝血 3ml,用全自动生化分析仪测定心肌酶、肝功能、肾功能等 10项 ,部分病人同时作心电图检查。结果 :2 6例ABO溶血症患儿心肌酶及同功酶活性均有不同程度增高 ,尤以CK、CK -MB活性明显升高 ,两组比较差异有非常显著意义 (P <0 .0 1)。治疗前后 ,高未结合胆红素、心肌酶比较 ,心肌酶升高与黄疸程度及时间、高度呈正相关 (r =0 .90 2 ) ,差异有非常显著意义 (P <0 .0 1)。结论 :新生儿病理性黄疸可出现心肌损害 ,与黄疸出现时间和程度有关。

Objective: To discuss floating and clinical value of myocardial enzymes in neonate unconjugated hyperbilirubinemia. Methods: Myocardial enzymes, hepatic and renal function were evaluated by automatic biochemistry analyzer before and after treatment in all 26 patients. Seventeen of the patients had electrocardiograph. Result: All of the patients had myocardial enzymes and isoenzymes activities elevated in various degree, especially CK and CK-MB. Increasing of myocardial enzymes was highly relevant to degree and duration of jaundice (r-0.902). Analysis showed statistical significance when comparing to the normal neonates with P<0.01. After treatment, total bilirubin and myocardial enzymes decreased obviously than pretreatment with P<0.01. Conclusion: Neonate pathological jaundice may induce myocardial impairment which is correlated with the degree and duration of jaundice.