凋亡——一个令人困惑的名称

Apoptosis:A Perplexed Name

就“细胞凋亡”这个热点名称进行探讨 ,从凋亡的起因及定义、由凋亡定义引起的哲学思考及就定义所做的建议进行分别论述。凋亡最初提出的是一种形态学特点 ,描述与坏死相对应的细胞解体的主动过程 ,之后大多数文章把凋亡定义为程序性的细胞死亡 ,并逐步演绎把死亡之前的细胞内生化变化称为凋亡。由此引起凋亡判断标准的混乱 ,并产生相关的药理学问题。细胞凋亡的实际情况与人类冠以的定义产生矛盾 ,其根本原因是真正实体与人为定义概念的哲学思维的混淆。提出应用直接描述真正实体的名称较凋亡更为可取。

To explore the focus topic 'Apoptosis', discuss respectively about the origin and definition of apoptosis, make a philosophical consideration of the definition and suggest other descriptive name for apoptosis. The term apoptosis describes an active process of cellular deconstruction originally contrasted morphologically with necrosis; afterwards many issues equate the term apoptosis with programmed cell death. When active cell death of all types became apoptosis, the presence of biochemical changes became the prime criterion for labeling dying cells as apoptotic. So there are confusion about the criterion of apoptosis and cause some pharmacological questions. The real circumstances of apoptosis are in contradiction with its definition. The roots of causation are the confusion of philosophical thought about a real entity and a created concept, and suggest that the direct description of entities is preferable to the confusing definition.