氮杂冠醚的合成

Synthesis of nitrogen heterocyclic crown ether

报道了在酸性条件下,以丙酮和吡咯为原料合成大环氮杂冠醚——卟吩环的合成方法,反应时间为7d,催化剂用甲磺酸,反应温度控制在5℃时,产率可达82%。

Nitrogen heterocydic crown ether--porphine ring was synthesized with acetone and pyrrole in acidic medium,methylsulfonic acid as catalyst,at 5℃ for 7 days.The yield is up to 82%.