高血压病患者冠状动脉病变积分与血压变异性的关系

Relationship between coronary artery score and blood pressure variability in patients with essential hypertension

目的 探讨高血压病患者冠状动脉病变积分 (CAS)与血压变异性的关系。方法 选择 4 32例因拟诊冠心病而行冠状动脉造影的高血压病患者为研究对象 ,以标准 Judkins法行冠状动脉造影术 ,计算机定量分析系统 (QCA)分析冠状动脉狭窄程度并计算 CAS。同时行 2 4 h动态血压监测 (ABPM)。结果 性别、2 4 h收缩压标准差 (2 4 hSTDs)、2 4 h最大平均动脉压 (MAPmax)、升主动脉内径 (Ao)、高密度脂蛋白胆固醇 (HDL - C)均与 CAS有显著相关关系。经多因素 L ogistic回归分析显示 ,2 4 h STDs、Ao与 CAS呈显著正相关。结论 2 4 h STDs、Ao与 CAS密切相关 ,是高血压病患者冠心病发生发展的良好的预测指标 ,并可应用于临床指导冠心病危险人群的早期干预。

Objective To evaluate the relationship between the Coronary Artery Score(CAS) and blood pressure variability in patients with essential hypertension. Methods 432 patients with essential hypertension were performed coronary angiography. The severity of coronary artery lessions was analysised by quantitive computer analysis system (QCA) to acquire CAS. At the same time ABPM were measured. Results Sex, 24hSTDs, 24hMAPmax, Ao and HDL-C significantly related to CAS. In a logistic multivariate analysis, 24hSTDs and Ao significantly related to CAS. Conclusions 24hSTDs and Ao closely related to CAS. They are predictors in patients with coronary artery disease with essential hypertension,and the results can be used in clinical indication.