系统性红斑狼疮患者血清Ⅳ型胶原和层粘蛋白的检测意义

Clinical implication of levels of serum collagen type Ⅳ and laminin in systemic lupus erythematosus

目的 探讨SLE患者血清中Ⅳ型胶原 (Ⅳ .C)和层粘蛋白 (LN)水平及其临床意义。方法 采用放射免疫法对4 2例SLE患者及 2 0例正常人血清Ⅳ .C及LN含量进行了测定。结果 SLE患者血清Ⅳ .C、LN水平明显高于正常对照组 (P <0 .0 1 ) ,活动期患者血清Ⅳ .C、LN水平明显高于稳定期 (P <0 .0 5 )。结论 血清Ⅳ .C、LN可能参与SLE的发病过程 。

Objective To measure levels of serum collagen type Ⅳ (Ⅳ.C) and laminin(LN) in systemic lupus erythematosus(SLE) and its clinical meaning.Method\ The levels of serum Ⅳ.C and LN in 42 patients with SLE and 20 normal subjects were measured by RIA,respectively.Results The levels of serum Ⅳ.C and LN in SLE were significantly higher than those of the controls. The levels of serum Ⅳ.C and LN in active SLE were significantly higher than those of in latent SLE .Conclusion Ⅳ.C and LN may play a role in the pathogenesis of SLE and can be considered as an index of disease activity and treatment effect.