C反应蛋白在急性脑梗死发病中作用机制的探讨

The action mechanism of C-reactive protein in acute cerebral infarction

目的 探讨急性脑梗死患者发病早期血浆中 C反应蛋白 (CRP)的变化规律和 CRP可能的致病机制。方法 采用免疫比浊法测定 4 0例急性脑梗死病人血浆中 CRP的含量 ,并与对照组进行比较。结果 急性脑梗死患者 CRP水平较对照组显著升高 [(10 .4± 2 .0 ) m g/ L;(5 .6± 1.9) mg/ L],差异有显著性 (P<0 .0 1)。按梗死面积分层后梗死面积大者其 CRP值在病程的各时点均高于其他两组 ,差异有显著性 (P<0 .0 1)。同时 ,无论梗死面积大小 ,血浆中 CRP水平在病后 4周均呈下降趋势 [(10 .0± 1.2 ) mg/ L ;(8.0± 1.4 ) m g/ L ;(6 .8± 2 .8) m g/L ]。结论 C反应蛋白不仅是评价急性脑梗死病情变化和近期预后的一项简便迅速的参考指标 ,而且 CRP可能从多角度、多层次参与了脑梗死疾病发病的病理生理过程。

Objective To discuss the action mechanism of C-reactive protein (CRP) by checking the plasma levels of CRP during the onset stage of acute cerebral infarction.Methods A clinical trial was done with a randomized,placebo-controlled method.Applying immunity turbidimetry to survey the plasma levels of CRP in 40 examples from acute cerebral infarction patients during 6 hours,comparing those with normal control group′s.Results As compared with the control group [control group:(5.6±1.9)mg/L],the plasma level of CRP increasedinthreeperiodsincerebralinfarctionpatients,[( 10.4±2.0 )mg/L;[KG*2]( 22.6±2.4 )mg/L;(8.7±3.2)mg/L] ,showing a higher level .CRP levels reached the highest level at the first weekend ,showing a higher level .CRP levels reached the highest level at the first weekend [ ( 22.6±2.4 ) mg/L].As patients symptom relieved,CRP tended to drop.Meanwhile,in the patients with a larger-area infarction the plasma level of CRP was higher than that in the patients with a middle-or small-area cerebral infarction.Conclusion C-reactive protein is not only a simple,convenient and quick reference index to evaluaing the change of patient′s condition and the prognosis in the near future,but involves in the pathophysiologic process of acute cerebral infarction from multiple directions.