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辐射对造血系统的影响 被引量：29

Hematopoietic system responses of ionization radiation exposure
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摘要 造血系统是电离辐射的主要危象器官。机体受到照射后,造血祖细胞、造血干细胞以及造血微环境等都会产生与照射剂量相关的损伤而影响造血机能。 Hematopoietic system is a crisis organ of ionization radiation cxposure. Hemopoietic pro-genitor cells, hematopoietic stem cells, hematopoietic microenvironment etc. show dose related damage after irradiaton, consequently, hematopoietic function is destroyed.
作者 周美娟 郑莉 丁振华
机构地区 第一军医大学放射医学教研室
出处 《国外医学（放射医学核医学分册）》 2004年第3期139-142,共4页 Foreign Medical Sciences(Section of Radiation Medicine and Nuclear Medicine)
关键词 电离辐射 造血干细胞 造血基质细胞 外周血细胞 ionization radiation hemopoietic stem cells hematopoietic microenvironment periph-eral blood cells
分类号 R594.8 [医药卫生—内科学]
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参考文献22

  • 1Watson GE, Pocock DA, Papworth D, et al. In vivo chromosomal instability and transmissible aberrations in the progeny of haemopoietic stem cells induced by high- and low-LET radiations[J]. Int J Radiat Biol, 2001, 77(4): 409-417.
  • 2Rudat V, Bachmann N, Kupper JH, et al. Overexpression of the DNA-binding domain of poly (ADP-ribose) polymerase inhibits rejoining of ionizing radiation-induced DNA double-strand breaks[J]. Int J Radiat Biol, 2001, 77(3): 303-307.
  • 3Inoue T, Hirabayashi Y, Mitsui H, et al. Survival of spleen colony-forming units (CFU-S) of irradiated bone marrow cells in mice: evidence for the existence of a radioresistant subfraction[J]. Exp Hematol, 1995, 23(12): 1296-1300.
  • 4Dainiak N. Hematologic consequences of exposure to ionizing radiation[J]. Exp Hematol, 2002, 30(6): 513-528.
  • 5Grande T, Varas F and Bueren JA. Residual damage of lymphohematopoietic repopulating cells after irradiation of mice at different stages of development [J]. Exp Hematol,2000, 28(1): 87-95.
  • 6Kreja L, Greulich KM,Fliedner TM, et al. Stable chromosomal aberrations in haemopoietic stem cells in the blood of radiation accident victims[J]. Int J Radiat Biol, 1999, 75(10): 1241-1250.
  • 7Lemischka IR. Mircroenvironmental regulation of hematoietic stem cells[J]. Stem Cells, 1997, 15(1): 63-68.
  • 8Charbord P, Tamayo E, Deschaseaux F, et al. The hematopoietic microenvironment: phenotypic and functional characterization of human marrow vascular stromal cells [J].Hematology, 1999, 4 (3): 257-282.
  • 9Yamada M, Suzu S, Tanaka- Douzono M, et al. Effect of cytokines on the proliferation/differentiation of stroma- initiating cells[J]. J Cell Physiol, 2000, 184(3): 3511-3515.
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国外医学（放射医学核医学分册）
2004年 第3期

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