摘要
[目的]探讨尿多酸肽对晚期非小细胞肺癌患者的细胞免疫功能的影响。[方法]45例晚期非小细胞肺癌患者。单纯化疗组26例,采用NP(NVB+DDP)方案化疗。尿多酸肽联合化疗组19例,NP方案化疗联合应用尿多酸肽静脉滴注4～8周。两组均于化疗前及化疗2周期后,采用流式细胞仪检测T细胞亚群。[结果]单纯化疗组化疗前、后CD3+、CD4+、CD8+以及CD4+/CD8+差异显著(P<0.05),化疗后免疫功能明显下降。尿多酸肽联合化疗组治疗前、后CD3+、CD4+/CD8+无显著性差异(P>0.05),免疫功能无明显变化。两组化疗后CD3+、CD4+以及CD4+/CD8+比较差异显著(P<0.01),联合尿多酸肽组化疗后免疫功能明显高于单纯化疗组。[结论]晚期非小细胞肺癌患者普遍存在免疫功能紊乱和低下,化疗使细胞免疫功能进一步降低,尿多酸肽能促进化疗患者细胞免疫功能的恢复。
To evaluate the effect of Urineside on immunity of patients with advanced non-small cell lung cancer.Forty-five patients with advanced non-small cell lung cancer were enrolled.Twenty-six patients received chemotherapy with NVB+DDP and 19 patients received the same regiment combined with Urineside for 4 to 8 weeks.The changes of T-lymphocyte subgroups were measured with the flow cytometry method before and after 2 cycles chemotherapy in the patients.The ratio of CD4+/CD8+ in patients with advanced non-small cell lung cancer before chemotherapy was significantly lower than that in control group(P<0.05). In the chemotherapy group, the count of CD3+?CD4+ cells and the ratio of CD4+/CD8+ lowered after chemotherapy(P<0.05), that indicates the immunity decreased after chemotherapy.In the Urineside group,no significant changes of CD3+ cells and the ratio of CD4+/CD8+ pre- and post-treatment were observed (P>0.05), the immunity had no significant changes.After chemotherapy,CD3+ and CD4+ cells and the ratio of CD4+/CD8+ of the two groups had significant difference,the immunity in Urineside group was obviously higher than that in chemotherapy group.[Conclusion]The immunity is suppressed in the patients with advanced non-small cell lung cancer.The immunity lowers after chemotherapy.Urineside can improve the cell immunity in patients undergoing chemotherapy.
出处
《中国肿瘤》
CAS
2004年第1期52-54,共3页
China Cancer
关键词
非小细胞肺癌
尿多酸肽
药物疗法
T细胞亚群
non-small cell lung cancer
urineside
drug therapy
T-lymphocyte subgroup
