结核分枝杆菌临床分离株耐药特点分析

Drug resistant characterization analysis of clinical isolated mycobacterium tuberculosis

目的 :分析临床分离结核分枝杆菌的耐药特点。方法 :用改良罗氏培养基间接药敏实验绝对浓度法检测结核菌的耐药情况。结果 :结核菌总耐药率 83.2 % ,耐多药率为 6 6 .4 %。其中初始耐药率 6 8.4 % ,初始耐多药率 36 .8% ,复治耐药率92 .4 % ,复治耐多药率 84 .7%。结论 :耐药及耐多药结核菌感染是临床治疗结核病的一个严重问题。临床分离结核杆菌耐药率和耐多药率高。分析临床分离株耐药特点 ,对控制结核病传染及指导临床合理用药具有重要意义。

Objective:To analyze drug resistant characterization of clinical isolated tubercle bacillus.Methods:Drug sensitivity was carried out by improved L-J culture drug susceptibility test(TB).Results:Total resistant rate of clinical isolated TB was 83.2%.The multi-drug resistant(MDR) rate was 66.4%. Initial resistant rates of single and multi-drug were 68.4% and 36.8%. Acquired resistant rates of single and multi-drug were 92.4% and 84.7%. Conclusion: Drug resistant TB infection is a serious problem in clinic. Single and multi-drug resistant rates are very high. Analysis of drug resistant characterization of clinical isolated TB is very important in tuberculosis control and clinical rational drug-use.