单甲基酯亚磺酸帕珠沙星盐的波谱学研究

SPECTROSCOPY STUDIES ON THE STRUCTURES OF PAZUFLOXACIN AND ITS MONOMETHYLSULFITE

帕珠沙星 (Pazufloxacin) ,(S) 7 ( 1′ 氨基环丙基 ) [N ,8 缩 ( 2″ 甲基 )乙氧基 ] 3 羧酸 6 氟 喹啉 [4]酮 (S) 7 ( 1′ Aminocyclopropy1 ) [N ,8 de] ( 2″ methy1 ) epoxyethane 3 Carbony1icacid 6 fluoro quino1 [4] one,及其单甲基酯亚磺酸盐是一种可望用于抗革兰氏阳性菌和阴性菌的防治药物 .本文采用1 HNMR、1 3CNMR、DEPT及二维谱1 H 1 HCOSY、HMQC、HMBC和IR、MS推证了单甲基酯亚磺酸帕珠沙星盐分子结构的正确性 ,并进行了1 H、1 3CNMR谱峰的全归属 .对其IR、MS各主要峰也进行了归属 .

S-7-(1′-Aminocyclopropy1-\-(2″-methy1-epoxyethane-3-Carbony1ic acid-6-fluoro-quino1-\-one (Pazufloxacin) and its monomethylsulfite are compounds that can be used for prevention and treatment of diseases caused by Granss positive and negative bacteria. Their structures of the two compounds were determined by employing the combination of different spectroscopy techniques (IR, MS, ~1H NMR, ^(13)C NMR, DEPT, ~1H-~1H COSY, HSQC, HMBC). ~1H and ^(13)C NMR chemical shifts of Pazufloxacin and its monomethylsulfite were assigned.