一个六烷氧基联苯衍生物的合成和NMR分析

SYNTHESIS AND NMR STUDIES OF A SIXALKYLOXYL BIPHENYL DERIVATIVE

以具有生物活性的 4,4′ 二甲氧基 5 ,6,5′,6′ 二亚甲二氧基联苯 2 羟甲基 2′ 甲氧甲酰基联苯 (DICYCOL)为先导化合物 ,经酰化、取代等步骤的结构修饰 ,合成了新化合物 4,4′ 二甲氧基 5 ,6,5′,6′ 二亚甲二氧基 2 {2 [4 ( 4 溴苯甲基 )哌嗪基 1 ]}乙酰氧甲基 2′ 甲氧甲酰基 联苯 .用 1DNMR、2DNMR、ESI MS等对该新化合物进行了结构表征 。

Some alkyloxyl-biphenyls show efficient biological activity. To find new compound with more effective activity, a new biphenyl compound, 4,4′-dimethoxy-5,6,5′,6′-dimethenedioxy-2-{2-[4-(4-bromobenzyl)piperazine-1-yl-]}acetoxymethyl-2′-methoxycarbonyl-biphenyl was synthesized from 4,4′-dimethoxy-5,6,5′,6′-dimethenedioxyl-2-hydroxymethyl-2′-methoxycarbonyl-biphenyl. The structure of the compound was determined by means of ~1H NMR, ^(13)C NMR, HMQC, HMBC, NOESY and ESI-MS.