吉马烷型倍半萜构型和构象的NMR数据分析

ANALYSIS OF THE CONFIGURATION AND CONFORMATION OF GERMACRANE TYPE SESQUITERPENOIDS

吉马烷型倍半萜是众多倍半萜结构骨架类型中最为丰富的一种 .由于它们是十元环化合物 ,因此在立体结构上有许多变化 .动力学NMR变温实验、一维NOE差谱及二维NOESY等核磁共振技术研究表明 ,吉马烷型倍半萜存在 4种构型异构体 ,每 1种构型又有多种不同的构象式 ,但总是倾向于形成最稳定的构象 .本文通过NMR数据分析对 4种构型式及每

Germacrane type sesquiterpenoids are the most abundant among all the sesquiterpenoid skeletons. Their stereostructures vary much because of the decacycle. There are four configurational isomers and every configuration has several different conformers of germacrane derivatives, which tend to exist as the most stable conformers. All these conclusions are established by NMR spectroscopic techniques, including dynamics NMR (DNMR), NOED and NOESY, etc. These four configurational isomers and their relatively stable conformers are summarized by analyzing NMR spectral data in this article.