摘要
目的 探讨替米沙坦对高血压病患者血管内皮功能的影响。 方法 46例轻、中度原发性高血压患者 ,给予替米沙坦 80mg/d ,共 6周。观察治疗前后的血浆内皮素 -1(ET -1)和一氧化氮 (NO)水平的变化。另设 40例为健康对照组。 结果 高血压病患者治疗前与对照组比较 ,其血浆ET -1水平明显升高 ,NO水平显著降低 ;经替米沙坦治疗后其ET -1明显下降 ,NO水平显著升高 ,与治疗前差别有显著性。 结论 替米沙坦能改善高血压病患者的血管内皮功能。
Objective To investigate the effect of Telmisartan on vascular endothelial function in patients with essential hypertension. Methods Forty-six patients with essential hypertension had been treated with 80mg Telmisartan per day for 6 weeks . Plasma ET-1 and NO were measured before and 6 weeks after treatment . Forty healthy adults served as controls. Result Before medication , ET-1 was higher and NO lower in treatment group than control group (P<0.05). In treatment group , ET-1 was significantly decreased and NO was significantly increased 6 weeks after treatment with Telmisartan (P<0.05) There was significant difference before and after treatment. Conclusion Telmisartan may improve the vascular endothelial function of patients with essential hypertension .
出处
《实用预防医学》
CAS
2004年第3期467-468,共2页
Practical Preventive Medicine
关键词
替米沙坦
原发性高血压
血管内皮功能
Telmisartan
Essential hypertension
Vascular endothelial function
