^(99)Tc^m-ECD SPECT非侵入性的定量测定平均CBFl和rCBF理论及其应用研究

Noninvasive quantitative measurements of mean regional cerebral blood flow using ^(99)Tc^m-ethyl cysteinate dimer

目的 定量评价大脑及局部的平均脑血流量 ,应用99Tcm 半双胱乙酯显像寻求建立一种非侵入性、便于临床应用的定量方法。方法 首先获得脑血流灌注指数 (BPI) ,再据经验方程获得大脑半球及局部脑血流量 ,并进行重复性研究。总计分析了正常对照组 2 0例 ,脑血管病组 2 7例 ;并且将正常对照组的脑血流量与文献报道的结果进行了比较。结果 本方法重复性好。正常对照组和脑血管病组BPI值存在明显差异性 (P <0 .0 1) ,而脑血流量亦存在明显差异性 (P <0 .0 1)。正常对照组大脑半球的脑血流量与文献报道的结果无明显差异性 (P >0 .0 5 )。结论 此种定量方法 ,简便易行 。

Objective A non invasive, simple method for the quantitative evaluation and measurement of mean cerebral blood flow (mCBF) is presented using radionuclide brain imaging with technetium 99m ethyl cysteinate dimer ( 99 Tc m ECD). Methods We firstly obtained the brain perfusion index (BPI), then described a further development of this method to measure regional mCBF(mrCBF) in conjunction with SPECT and empirical equation. This method of measuring mCBF from SPECT was validated in 20 normal control subjects and 27 patients with cerebrovascular diseases and the reproducibility of the method was investigated. Results The results showed a high degree of reproducibility of the method. The mean whole brain BPI of cerebrovascular patients was significantly lower than that of normal controls ( P <0.01). Simultaneously the mean CBF of cerebrovascular patients was significantly lower than that of normal controls ( P <0.01). The mrCBF between in normal subjects and results reported by data had no significant difference. Conclusion The quantitative method of graphical analysis permits the routine measurement of mrCBF from 99 Tc m ECD SPECT tomograms of perfusion. The method is non invasive (without any blood sampling) and has a prospective application and practically clinical value.