奥曲肽治疗消化道大出血的疗效观察

Effect of Octreotide on massive gastrointestinal hemorrhage

目的 :观察奥曲肽治疗急性消化道大出血的疗效。方法 :奥曲肽治疗组 31例 ,予奥曲肽10 0ug静注 ,以后 2 5ug/h静滴 ,持续 3～ 5d。垂体后叶素对照组 30例 ,予垂体后叶素 5 0u/ 8h静滴 ,持续3～ 5d。结果 :奥曲肽治疗组总有效率 90 .3% ,止血时间 (2 4± 5 )h ,再出血率 6 .4 5 % ,明显优于垂体后叶素对照组 [分别为 6 3.3%、(4 5± 6 )h和 13.3% ]。结论 :奥曲肽是治疗急性消化道大出血的有效药物。

Objective: To observe the effect of Octreotide on acute massive gastrointestinal hemorrhage. Methods: 31 patients of Octreotide therapy group(M19, F12;age 49a±12a)received Octreotide 100ug by injection;and then were given at a dosage of 25ug intravenously once hours iv, persisting for 3～5d.Pituitrin control group(M19,F11;age47a±13a)received a dosage of 50u intravenously once every eight hours, persisting for 3～5d. Results : Effective rate of Octreotide therapy group was 90.3%.Hemostasia times were(24±5)h. Recurring hemorrhage rate was 6.45%. They were significantly better than Pituitrin group[effective rate of 63.3%,hemostasia times of(45±6)h, recurring hemorrhage rate of 13.3%].Conclusions: Octreotide is effective in the treatment of acute massive gastrointestinal hemorrhage.