评价孕早期血β绒毛膜促性腺激素水平对辅助生殖治疗后妊娠结局的预测

Appraising the serum β-human chorionic gonadotropin as a predictor for outcome of pregnancy after assisted reproductive technology

目的 :探讨辅助生殖技术治疗后早孕期血β绒毛膜促性腺激素 (β -HCG)水平的单次及动态测定对预测妊娠结局的临床意义。方法 :对在本中心采用辅助生殖技术治疗受孕的不孕症患者监测排卵后 16d的血 β -HCG水平及其上升情况 ,追踪妊娠结局 ,按妊娠是否超过孕 12周分为继续妊娠组及不良妊娠组。结果 :血β -HCG水平与妊娠结局明显相关 ,排卵后 16d首次血β -HCG值在继续妊娠组显著高于不良妊娠组 (P <O .0 1) ,血β -HCG <10 0IU/L者 87.5 %有不良妊娠结局 ,而血β -HCG>4 0 0IU/L ,则 97.3%的患者妊娠超过 12周。首次验血后 4 8h血β -HCG的上升幅度在继续妊娠组和不良妊娠组之间差异无显著性 (P >0 .0 5 )。结论 :辅助生殖技术中排卵后 16d单次血 β -HCG值是一项有意义的预测妊娠结局的指标。

Objective: To investigate the clinical significance of the level of serum β-human chorionic gonadotropin(β-HCG) as an indicator for outcome of early pregnancy after assisted reproductive technique(ART).Methods: The clinical date of infertile women in ART pregnancies was analyzed. The serum β-HCG was regularly monitored ,and the pregnancy outcome was recorded. Results: The levels of β-HCG showed significant correlation with consequence of ART pregnancy. The low levels of β-HCG(<100 IU/L) were associated with a probability of the poor pregnancy outcome(87.5%), whereas levels >400IU/L predicted a 97.3% chance of gestational age>12 weeks. There was no significant difference in the rising range of 48 hours after the first serum β-HCG tested between the two groups. Conclusions: A single serum β-HCG level at 16 days after ovulation is a useful predictor for pregnancy outcome.