慢性病毒性肝炎合并风疹病毒感染分析

Analysis of rubella virus co-infection in patients with chronic virus hepatitis.

探讨慢性病毒性肝炎合并风疹病毒 (RubellavirusRV)感染对肝功能及病毒复制的影响。对 30例慢性病毒性肝炎分别检测了抗 -RVIgM、HBV血清学标志物、抗 -HCV抗体及生化指标 ;另选择 2 0例健康人检测抗 -RVIgM做对照。慢性乙型肝炎病例中抗 -RVIgM阳性率为 4 5 4 % ,慢性丙型肝炎病例中抗 -RVIgM阳性率为4 7 5 %。血清抗 -RVIgM阳性的慢肝患者ALT、γ -GT水平及肝功能复常天数均明显升高和延长 ,并多伴有发热、呕吐、肝大症状或体征的加重。慢性病毒性肝炎合并风疹病毒感染可加重肝功能障碍同时延长病情恢复。

To investigate the effect of rubella virus (RV) Co-infection on fluctuation of liver function and HBV replication in patients with chronic viral hepatitis. Sera from 32 cases with chronic viral hepatitis were defected for RV IgM antibodies, HCV antibodies, sera sign of HBV and biochemical perameters. Control sera taken from twenty normal persons were tested for RV IgM antibodies. Frequency of RV IgM antibodies in patients with chronic hepatitis B was 45.4%, in patients with chronic hepatitis C were 47.5%. Levels of total γ-GT and ALT in RV positive cases were higher than those in RV sera negative ones. Their convalescences of liver function become longer, accompanying with the aggravation of fever, vomit and hepatomegaly. The results suggested that the patient's liver dysfunction was deteriorated by RV Co-infection.