胃癌增殖活性的研究—Ki—67单克隆抗体标记与核分裂计数对比观察

STUDY OF PROLIFERATIVE ACTIVITY IN GASTRIC CARCINOMA:COMPARISON BETWEEN Ki-67 LABELING RATES AND MITOTIC COUNT

作者用Ki—67单克隆抗体对30例胃癌标本做了免疫组化标记观察,并与核分裂计数作了对比研究.结果发现Ki—67标记阳性率在6.3%～81.3%之间(平均33.04±21.94),Ki—67标记阳性率与核分裂计数之间呈显著正相关(r=0.686,P<0.01),未发现Ki—67标记阳性率在有无淋巴结转移、胃壁侵犯深度、不同分化程度和生长方式之间存在差异( P >0.05).

30 cases of gastric carcinoma were studied by immunostaining with monoclonal antibody Ki -67. The results demonstrated that the Ki -67 labeling rates ranged from 6. 3%~81. 3% (mean 33. 04±21. 94). A significant positive correlation was found between Ki- 67 labeling rates and mitotic count(r=0. 686,P <0. 01). There was no correlation between Ki-67 labeling rates and nod) 1 status,wall invasion,degree of differentiation as well as growth patterns.