早期胎传梅毒15例回顾性分析

The Retrospective Analysis of 15 Cases of Early Congenital Syphilis

目的 探讨早期胎传梅毒的临床表现。方法 回顾性分析本院 1999年 5月～ 2 0 0 3年 3月收治的 15例早期胎传梅毒。结果 皮肤损害 15例 ,早产儿 8例 ,低体重儿 9例 ,贫血 12例 ,肝脾肿大 11例 ,骨损害 1例 ,鼻炎 4例 ,新生儿肺炎 4例。梅毒血清学检查 :TPPA阳性 15例 ,RPR阳性 14例。选用青霉素治疗 ,临床症状消失 5例 ,好转 8例 ,死亡 1例 ,放弃治疗 1例。发生吉海反应 2例。结论 典型皮肤损害可作为早期胎传梅毒诊断的主要依据 ;对不明原因的新生儿贫血应警惕胎传梅毒 ;治疗中可发生吉海反应应引起注意。

Objective To investigate the clinical manifestations of early congenital syphilis. Methods 15 cases of early congenital syphilis were retrospectively studied.Results There were 15 cases with cutaneous lesions, 8 cases with premature delivery,9 cases with low birth weight,12 cases with anaemia,11 cases with hepatosplenomegaly,1 case with bone lesion,4 cases with syphilitic rhinitis,4 cases with neonatal pneumonia.Serological test results were as follows:There were 15 cases with TPPA positive,14 cases with RPR positive.15 cases were treated with penicillin.All clinical symptoms resolved in 5 cases; 8 cases improved;1 case died;1 case abandoned the treatment.Jarisch-Herxheimer reaction occurred in 2 cases.Conclusion The typical cutaneous lesions are regarded as the diagnostic main basis of congenital syphilis;Anaemia of unknown cause may be induced by congenital syphilis that deserved great attention;In the treatment,the occurrence of Jarisch-Herxheimer reaction is brought attention.