慢性病毒性肝炎血瘀证患者肝功能及肝纤维化血清学指标的临床研究

Observation on the Changes of Liver Function and Fibrosis Serum Markers in Blood Stasis Syndrome of Chronic Hepatitis B

目的 :探讨慢性病毒性肝炎血瘀证患者的血清肝功能及肝纤维化指标变化。方法 :根据临床症状将患者分为血瘀证组和非血瘀证组 ,观察两组患者的血清丙氨酸转氨酶 (ALT)、天门冬氨酸转氨酶 (AST)、白蛋白 (Alb)、球蛋白 (Glb)、A/G、肝纤 4项 (HA、LN、ⅣC、PCⅢ )水平 ,并进行对照。结果 :血瘀证患者的HA、LN、Ⅳ C值的平均秩 (MEANRANK )分别为 3 1 5 2、 3 1 96、 3 2 0 6,高于非血瘀证组 ,P <0 0 5。而ALT、Alb、Glb、A/G及PCⅢ经检验P >0 0 5 ,提示血瘀证组与非血瘀证组差异无显著性意义。结论 :病毒性肝炎血瘀证患者肝组织内存在活动性肝纤维化 ,提示肝病的慢性化趋势。

Objective:To observe the changes of liver function and fibrosis serum markers in blood stasis Syndrome of chronic hepatitis B. Methods:52 patients with chronic hepatitis B were divided into group 1(blood stasis) and group 2(non-blood stasis) according to clinical symptoms. Serum ALT, AST, Alb, Glb, A/G, HA, LN, Ⅳ-C, PCⅢ were measured in the above patients. Results: The serum levels of HA,LN,Ⅳ-C were gradually increased in group 1, there was significant difference between the two groups(P<0.05). But there were no change in serum ALT, AST, Alb, Glb, A/G, PCⅢ.Conclusion:In the patients with chronic hepatitis B, there is a significant correlation between blood stasis Syndrome and liver fibrosis.