甲状腺癌肥大细胞和肿瘤相关巨噬细胞定量研究

Study on the counts of mast cells and tumor-associated macrophages in the thyroid cancer tissues

目的研究甲状腺癌组织中浸润的MC和TAM数量及其临床病理意义。方法50例甲状腺癌外科手术切除标本常规制作石蜡包埋切片,染色方法为ABC免疫组化法。结果50例甲状腺癌MC和TAM定量分别为(16.5±5.6)个/HP和(19.6±7.4)个/HP;乳头状腺癌和颈淋巴结未转移病例MC和TAM定量明显低于未分化癌和颈淋巴结转移病例,差异均有显著性(P<0.05),滤泡状腺癌和髓样癌介于两者定量介于乳头状腺癌和未分化癌之间,均差异无显著(P>0.05)。结论MC和TAM可能是反映甲状腺癌进展、转移及预后的重要指标。

Objective:To study on the counts of mast cells(MC),tumor-associated macrophages(TAM)and their clinicopathological significances in the thyroid cancer tissues.Methods:Immunohistochemical method was used on the routinely paraffin embedded sections of surgical operated specimen with thyroid carcinoma.Results:The counts of MC and TAM in50cases of thyroid carcinoma were(16.5±5.6)/HP and(19.6±7.4)/HP,respectively.The counts of MC and TAM were significantly lower in the cases of papillary adenocarcinoma,and without-metastasis of neck lymphnode than that in the ones of undifferentiated carcinoma,with-metastasis of neck lymphnode(P<0.05).No statistical differences were found(the counts of MC or TAM)in the cases of follicular adenocarcinoma or medullary carcinoma with papillary adenocarcinoma or undifferentiated carcinoma(P<0.05).Conclusions:MC and TAM in cancer tissues might be an important marker in the reflecting the progress,metastasis and prognosis of thyroid cancer.