乌拉地尔治疗重度妊娠高血压综合征的疗效及安全性

The Efficacy and Safety of Urapidil in Treating Patients with Severe Pregnancy Induced Hypertension

目的 探讨乌拉地尔对重度妊娠高血压综合征的临床疗效及安全性。方法 132例重度妊高征患者随机分为两组 ,分别给予乌拉地尔和酚妥拉明治疗。两组均予持续心电监护和血压监测 ,在治疗开始前半小时内每 5min 1次 ,以后每小时 1次记录血压、心率的变化 ,并观察不良反应。结果 治疗组总有效率97 0 % ,起效时间为 ( 4 2± 2 8)min ,症状改善时间为 ( 2 6 6± 8 8)min ,与对照组的 95 5 % ,( 3 9± 2 6 )min ,( 38 7± 13 5 )min相比 ,前二者无显著性差异 (P >0 0 5 ) ,后者有显著性差异 (P <0 0 5 )。两组治疗后血压较治疗前均有显著下降 (P <0 0 5 ) ,治疗组心率改变不明显 ,对照组用药后 30min～ 2h心率加快 ,与用药前比较差异显著 (P <0 0 5 ) ,至用药后 4h才恢复用药前水平。治疗组降压平稳 ,未发现严重不良反应。结论 乌拉地尔治疗重度妊高征起效快 ,降压平稳 ,安全性高。

Objective To evaluate the efficacy and safety of urapidil in patients with severe pregnancy induced hypertension syndrome (PIH). Methods 132 patients with severe PIH were divided randomly into two groups. BP and heart rate were monitorred. BP,heart rate and side effects were recorded at every 5 mins in the first 30 mins and each 1hr in 1_12 hr after treatment. Results The total effective rate,effective time were 97 0%,(4 2±2 8)min for treatment group and 95 5%,(3 9±2 6)min for control group. There is no significance between two groups ( P >0 05). The optimal time was significantly quicker in treatment group than in control group (26 6±8 8min Vs 38 7±13 5min, P <0 05). After treatment,BP was significantly reduced in both groups. Heart rate was not changed in treatment group,but it was significantly quicker in control group. No obvious side effects were observed in treatment group. Conclusions Urapidil is effective and safe in treatment of severe PIH.