肠宁(CN)的急性及蓄积毒性试验研究

Studies on the Toxicity Test of CN

为了提供中药肠宁(CN)的安全毒理学评价资料,本试验采用改良Karber法测定小白鼠的 LD50＞60 973 mg/kg;在蓄积毒性试验中,小白鼠未表现出蓄积毒性。这说明中药肠宁属于实际无毒 性物质,并无蓄积毒性作用。

To improve safety toxicology evaluation material of CN, The test of LD50 was examined by the better Barber means; The accumulative toxicity test was studied by the twenty-day accumulative test in mice .The results demonstrated that LD50 was over 60 973mg/kg in the acute toxicity test; there was not obvious accumulatively in mice in the accumulative toxicity test .The results suggested that CN was Impoisonous material.