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密码子上下文关联与蛋白质二级结构 被引量：1

Codon Context and Protein Secondary Structure
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摘要 对人(Homosapiens)的117个蛋白质和大肠杆菌(Ecoli)的87个蛋白质的各二级结构相对应的mRNA序列中的密码子上下文关联作了统计分析,发现它们的使用对不同种属的蛋白质二级结构有不同的偏好,对同一种属蛋白质的不同二级结构也有不同的偏好.与密码子和单碱基关联的结果比较,说明密码子上下文关联可以更加准确地预测蛋白质二级结构. The contexts of codons in mRNA sequences corresponding to the secondary structures of 117 Human and 87 Ecoli proteins are statistically analyzed. It is shown that the usage context of codons are biased in the same type of secondary structures of proteins of different species and in different types of secondary structures of proteins of the same species.Comparing with the correlation base and codons,the result implies that the contexts of codons can provide additional information for predicting the secondary structures of proteins.
作者 胡秀珍 黄延昭 肖奕
机构地区 内蒙古大学物理系 华中科技大学物理系
出处 《内蒙古大学学报（自然科学版）》 CAS CSCD 北大核心 2004年第4期408-412,共5页 Journal of Inner Mongolia University：Natural Science Edition
基金 国家自然科学基金资助(90103031) 内蒙古自然科学基金资助(20001301)
关键词 蛋白质二级结构 同义密码子 密码关联 稀有密码子 secondary structure of protein context of codons synonymous codon rare codon
分类号 Q61 [生物学—生物物理学]
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参考文献13

  • 1Komra A A,Lesnik T,Reiss C.Synonymous codon substitutions affected ribosome traffic and protein folding during in vitro translation [J].FEBS Lett,1999,462:387～391.
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二级参考文献3

共引文献6

同被引文献12

  • 1Komra A A,Lesnik T,Reiss C. Synonymous codon substitutions affected ribosome traffic and protein folding during in vitro translation [J].FEBS Lett,1999,462:387～391.
  • 2Adzhubei A A,Adzhubei I A,Krasheninnikov I A,et,al.Non-random usage of degenerate codons id related to protein three-dimensional structure [J].FEBS Letters,1996,399:78～82.
  • 3Adzhubei I A,Adzhubei A A,Neidle S.An Integrated Sequence-Structure Database incorporating matching mRNA sequence,amino acid sequence and protein three-dimensionalstructure data [J].Nucleic Acids Res,1998,26:327～331.
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  • 7Kabsch W,Sander C.Dictionary of protein secondary structure:Pattern recognition of hydrogen-bonded and geometrical features [J].Biopolymers,1983,22:2577～2637.
  • 8Shpaer E.Constraints on codon context in Escherichia coli genes:their possible role in modulating the efficiency of translation [J].J Mol Biol,1986,188:555～564.
  • 9Chou P Y,Fasman G D. Prediction of the secondary of structure of protein from their amino acid sequence [J].Adv.Enzymol. Relat. Areas. Mol. Boil.1978,47:45～147.
  • 10Xie T,Ding D F. The relationship between synonymous codon usage and protein structure [J].FEBS Letters,1998,434:91～96.

引证文献1

内蒙古大学学报（自然科学版）
2004年 第4期

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