多种肿瘤标志物蛋白芯片检测系统对恶性肿瘤的临床应用价值

Clinical Value of Multiple Tumor Markers Protein Biochip Detective System for Malignant Tumor

目的 研究多种肿瘤标志物蛋白芯片检测系统对恶性肿瘤诊断的临床意义。方法 用该检测系统测定分析 4 6 9例恶性肿瘤患者 ,130例良性疾病患者和 14 4 8例健康查体者血清中 12种常见肿瘤标志物 (CA199,NSE ,CEA ,CA2 4 2 ,CA12 5 ,CA15 3,AFP ,Ferrtin ,free PSA ,PSA ,β HCG及HGH)的水平。结果 恶性肿瘤组的阳性率为 81.4 5 % ,显著高于良性疾病组 (5 0 .0 0 % )和健康查体组 (2 9.77% ) (P <0 .0 5 )。除胰腺癌之外 ,联合检测对其余 14种恶性肿瘤的敏感性均显著高于单一标志物检测 (P <0 .0 5 )。结论 运用蛋白芯片技术联合检测多种肿瘤标志物可以明显提高恶性肿瘤诊断的敏感性 ,同时也可以作为无症状人群的早期肿瘤普查手段之一 ,尤其对肿瘤高危人群的防癌普查具有一定意义。

Objective To evaluate the clinical significance of multiple tumor markers protein biochip detective system for malignant tumor diagnosis.Methods The serum levels of 12 common tumor markers,including CA199,NSE,CEA,CA242,CA125,CA153,AFP,Ferrtin,free?-?PSA,PSA,β?-?HCG and HGH,were measured with the detective system in 469 malignant tumor patients,130 patients with benign disease and 1448 healthy examinations.Results The positive rates were 81.45% , 50.00% and 29.77% in malignant tumor, benign disease and healthy groups,respectively. The malignant tumor group had significantly higher positive rate than that of the controls ( P < 0.05 ). Except for pancreatic cancer,combined measurement had higher sensitivity than single tumor marker for the other 14 kinds of malignant tumors ( P < 0.05 ).Conclusion Combined measurement of multiple serum tumor markers using protein biochip technique can significantly increase the diagnostic sensitivity for malignant tumor,but also can be used as an earlier period tumor surveying tool to symptomless people,especially to high risk people.