低氧诱导因子-1结构、活性调节及其靶基因的研究进展

Progress in the study on the structure, activity regulation and target genes of hypoxia-inducible factor 1

低氧诱导因子 1(hypoxia induciblefactor 1,HIF 1)是由低氧等诱导细胞产生的一种转录因子 ,通过调控近 5 0种靶基因 ,引起细胞对低氧发生一系列适应性反应 ,以实现其主要调节氧稳态的功能 ,说明其在低氧信号转导过程中起关键作用 ,具有重要的生理学和病理生理学意义。本文综述了HIF 1的结构。

Hypoxia-inducible factor 1(HIF-1) is a heterodimeric transcription factor that functions as a master regulator of mammalian oxygen homeostasis. Under hypoxic conditions HIF-1 becomes activated and up-regulates downstream target genes. HIF′s function of oxygen homeostasis is achieved by regulating about 50 target genes which encode proteins that mediated the adaptative responses of the cell to hypoxia. Therefore, HIF-1 plays a pivotal role in the process of hypoxia signal transduction, being of very important significance in physiology and pathophysiology. In this review, some of the latest advances of research in HIF-1 structure, activity regulation and target genes are summarized.