铅作业工人肾损伤某些生化指标的变化

Changes on certain biochemical indexes for renal injury in workers exposed to lead

目的 探索铅致肾损伤生化指标的变化。方法 观察了某蓄电池厂 10 3名铅作业工人尿总蛋白(TP)、尿β2 微球蛋白 (β2 MG)、尿N 乙酰 β D 氨基葡萄糖苷酶 (NAG)的变化 ,同时分析尿铅含量、接触工龄与三指标的关系。结果 接触组尿TP(5 9 73± 6 84 )mg gCr、尿 β2 MG(12 2 0 1± 1 2 5 ) μg gCr、尿NAG(13 70±1 6 2 )U gCr水平显著高于对照组 ,且随尿铅含量的增高而升高。尿NAG的活性在接触铅 1～ 3年明显高于对照组 ,先于尿TP、尿 β2 MG出现异常。结论 尿NAG活性升高可能反映肾小管细胞损伤。尿NAG活性变化 ,结合尿β2 MG或尿TP的变化 ,可能反映肾受损情况。

Objective To explore changes of biochemical indexes for renal damage induced by lead. Methods Contents of urinary total protein(TP), urinary β 2-microglubin (β 2-MG) and urinary-Acety- D-glucosamindase (NAG) activity of 103 workers in one storage battery plant were observed, then the relationships among work standing, urinary lead (Pb) content and three indexes were analyzed. Results The levels of urinary TP(59.73±6.84)mg/gCr, urinary β 2-MG(122.01±1.25)μg/gCr and urinary NAG (13.70±1.62)U/g Crin exposed group were more higher than those in the control group and increased along with the rising level of urinary lead. The activities of urinary NAG in group of exposure years from 1 to 3 years were more higher than those in the control group. Increase in urinary NAG activity appeared earlier when compared with changes in urinary TP and β 2-MG. Conclusion The change of NAG activity could reflect earlier the injury of the proximal tubular cells when compared with changes in urinary TP and β 2-MG. The change of urinary NAG activity, together with change of urinary β 2-MG or TP, could reflect the status of renal damage in lead-exposed workers.