罗格列酮治疗2型糖尿病多项目临床观察

Clinical observation of rosiglitazone for type 2 diabetes mellitus

目的 :观察罗格列酮单独及联合用药治疗 2型糖尿病 ,改善胰岛素抵抗及恢复胰岛 β细胞功能的有效性、安全性及不良反应。方法 :按照 1999年WHO制定的诊断标准确诊为 2型糖尿病 10 8例 ,其中 3 0例为初诊未接受药物治疗2型糖尿病 ,饮食及运动治疗 3周 ,血糖控制不佳 ;单独应用胰岛素治疗血糖控制不佳 2 1例 ;服用二种常规口服降糖药血糖控制不佳者 5 7例 ,疗程 12周 ,均在原有治疗不变的基础上加用罗格列酮 4mg ,1次 /d。结果 :10 8例共有 6例退出。治疗前后平均血糖下降 3 5 %,糖化血红蛋白下降 1.5 %,HOMA IR值降低 5 0 %,β细胞功能恢复 5 3 %。 结论 :罗格列酮单独及联合口服降糖药、胰岛素 ,能显著降低血糖水平 ,提高胰岛素的敏感性 ,无明显不良反应。

Objective To observe the effect,safty and adverse effect of rosiglitazone to improve insulin resistance and β cell function for singleness and combination therapy in patients with type 2 diatetes mellitus. Methods In 108 patients whose glucose level did not reach the criteria according the 1999 WHO diagnostic criteria,30 cases were given diet and sport treatment strictly for 3 weeks,21 cases were given insulin,and 57 cases were given two oral drugs all for 12 weeks.All these 108 cases were given 4 mg rosiglitazone once a day.Rusults Six cases were excluded. The glucose levels were decreased 35%, HbA1C 1.5%, HOMA IR 50%, and β cell function was increased 53% before and after treatment. Conclusion Single rosiglitazone or combined with orgal drugs and insulin can decrease glucose level and increase insulin sensitivity with no obvious adverse effect.;