原发性高血压患者血清胰岛素样生长因子Ⅱ和生长激素的变化

Change of serum insulin-like growth factor Ⅱ and serum growth hormone in essential hypertension

目的:探讨原发性高血压患者血清胰岛素样生长因子Ⅱ(IGFⅡ)和生长激素(GH)含量的变化及其临床意义。方法:用放射免疫法测定92例原发性高血压(EH)患者和45例非高血压患者的血清IGFⅡ和GH的水平,并进行对照统计分析。结果:EH组血清IGFⅡ水平显著高于对照组(P<0.01),而GH水平显著低于对照组,2参数间呈显著负相关(P<0.05),IGFⅡ与平均动脉压成显著正相关(P<0.05),GH与平均动脉压、体重指数均无相关性意义。男女组间2参数比较亦无统计学差异。在高血压Ⅰ、Ⅱ、Ⅲ期组间,血清GH水平依次递减(F检验,P<0.01),且Ⅲ期组显著低于Ⅰ期组(P<0.05),伴心脑肾并发症组血清GH水平也显著低于无并发症组(P<0.05);血清IGFⅡ水平3期间则均无显著差异。结论:EH患者血清IGFⅡ水平显著升高,而GH水平显著降低,两参数间呈负相关。

Objective: To investigate the changes of serum insulin-like growth factor Ⅱ(IGFⅡ) and growth hormone (GH) in patients with essential hypertension (EH). Methods: Serum IGFⅡ and GH were studied in 92 EH cases by radioimmunoassay, 45 normtensive patients served as control. Results: Serum IGFⅡincreased significantly in EH patients compared with that in control group (P<0.01), but Serum GH decreased significantly. The serum IGF Ⅱ level was negative significantly correlated with the GH (P<0.05). IGF Ⅱ was positively significantly correlated with the mean artery pressure level (P<0.05), but GH was not so. The difference in the mean serum GH levels was significant in different stages (stageⅠ.Ⅱ.Ⅲ) of EH patients (P<0.01). GH levels in EH patients with heart and/ or brain and/or renal complications were significantly lower than without complications (P<0.05), but no significantly change for IGFⅡ. Conclusion: Serum IGFⅡ significantly increased but GH significantly decreased in EH patients.