静脉注射胺碘酮对冠心病快速型室上性心动过速的疗效

Effects of intravenous amiodarone in treatment of coronary heart disease with supraventricular tachycardia

目的:观察静脉注射胺碘酮治疗冠心病快速型室上性心律失常(SVT)的疗效。方法:入选冠心脏病合并SVT患者,心动过速发作1～6h 79例,随机分为胺碘酮组(41例,脉注射胺碘酮150～450mg或改为静脉恒速泵注入),毛花甙C组(38例,静脉注射毛花甙C 0.4～1.0mg),观察其心率、QT间期变化及药物副作用。结果:两组心率均有明显控制,肢碘酮和毛花甙C组对STCA的有效率分别为92.6％与73.6％,胶碘酮疗效高于毛花甙C(P<0.01),QT间期及副作用差异无显著性意义。结论:胺碘酮对冠心病并SVT者的疗效显著高于毛花甙C。

Objective: To study the clinical effects of intravenous amiodarone in treatment of coronary heart disease (CHD) with supraventricular tachycardia (SVT) in control of heart rates. Methods: The efficacy and safety of amiodarone were studied in 79 patients with SVT 1～6 h in duration. The amiodarone 150～450 mg or cedilanid 0.4 ～1.0 mg were given intravenously. The heart rates, QTduration and side effects of the drugs were observed during study. Results: In 41 patients of group of amiodarone and 38 patients of group of cedilanid that heart rates were controlled, the effective rate was 92.6% and 73.6% respectively. QT duration had no significant change. Conclusion: Amiodarone is more effective than cedilanid in CHD patients with SVT.