培哚普利治疗高血压患者左室舒张功能的疗效

Effect of perindopril on left ventricular diastolic function in patients with essential hypertension

目的:观察培哚普利对原发性高血压(EH)患者左心室舒张功能的影响。方法:采用自身对照开放试验方法,观察50例EH患者培哚普利治疗6月后,左心室舒张内径(LVDd)、舒张期室间隔厚度(IVST)、舒张末期左心室后壁厚度(LVPWT)、左心室重量指数(LVMI)、二尖瓣口E峰、A峰、A/E比值的变化。结果:50例EH患者治疗6个月后,IVST、LVPWT、LVMI明显下降(P<0.05),A峰、A/E比值亦明显下降(P<0.05)。结论:培哚普利在降压的同时,不但能逆转左心室肥厚,并且能有效改善左心室舒张功能。

Objective: To study the effect of perindopril on left ventricular diastolic function in patients with essential hypertension (EH). Methods: A self control, open clinical trial was carried out to observe the effect of perindopril of left ventricular diastolic function in patients with EH. Ultrasonic scanning and mitral blood speed analysis were performed in all 50 patients and results were compared before and after 6 months treatment. Results: After 6 months treatment with perindopril (4 mg/d or 8 mg/d), ultrasonic scanning comparison indicated that IVST. LVPWT. LVMI significantly lowered (P<0.05), VA and A/E ratio significantly decreased (P<0.05). Conclusion: Perindopril can not only decrease blood pressure, but also can improve left ventricular diastolic function and decrease left ventricular hypertrophy at the same time.