嗜麦芽窄食单胞菌的药敏及最低抑菌浓度分布分析

Antimicrobial susceptibility and distribution of minimal inhibitory concentration of Stenotrophomonas maltophilia

目的 分析临床分离到的嗜麦芽窄食单胞菌的药敏试验结果及其对临床常用抗菌药物的最低抑菌浓度 (MIC)分布情况。方法 用法国生物梅里埃公司新近推出的全自动微生物鉴定仪进行菌种鉴定及药敏分析。结果 嗜麦芽窄食单胞菌对磺胺甲唑 /甲氧苄啶复方制剂和喹诺酮类的左氧氟沙星敏感率分别达 79.31%和72 .4 1% ,对其他抗生素的敏感率相对较低。 79%菌株对磺胺甲唑 /甲氧苄啶复方制剂的MIC≤ 4 μg/ml;93%菌株对左氧氟沙星的MIC≤ 4 μg/ml。 结论 嗜麦芽窄食单胞菌主要引起呼吸系统的感染 ,多重耐药性情况十分严重。对其感染的治疗 ,应在抗生素敏感试验及其MIC的指导下进行。

Objective To study the antimicrobial susceptibility and distribution of minimal inhibitory concentration of the clinical isolated Stenotrophomonas maltophilia . Methods The Stenotrophomonas maltophilia was identified and detected with Bio merieux VITEK Ⅱ automated microbial indentification system. Results The antimicrobial susceptibility rates to Stenotrophomonas maltophilia of sulfamethoxazole trimethoprim (SMZ/TMP) and levoflixacin were 79.31% and 72.4% respectively, and it was lower comparing to other antibiotics. The minimal inhibitory concentraction of 79% Stenotrophomonas maltophilia to SMZ/TMP was ≤4 μg/ml. The minimal inhibitory concentraction of 93% Stenotrophomonas maltophilia to levoflixacin was ≤4 μg/ml. Conclusions Stenotrophomonas maltophilia mainly caused respiratory tract infection in patients and mulitidrug resistance is serious. In treating Stenotrophomonas maltophilia infection, antimicrobial drugs should be selected according to the results of antimicrobial susceptibility test and minimal inhibitory concentration.