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骨桥蛋白与胃癌侵袭转移关系的研究

Relationship of Osteopontin Expression With Invasion and Metastasis of Gastric Cancer
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摘要 目的 :初步探讨骨桥蛋白 (Osteopontin ,OPN)与胃癌侵袭转移的关系。方法 :采用免疫组织化学SABC方法检测 12例非癌胃组织和 72例胃癌标本中OPN的表达及分布。结果 :(1) 12例非癌胃组织、30例无淋巴结转移和 2 6例有淋巴结转移及 16例有淋巴结转移且伴胃外器官转移的胃癌组织中 ,OPN的阳性表达率分别为 0、4 3 3% (13/30 )、76 92 % (2 0 /2 6 )和 87 5 % (14 /16 ) ;(2 )淋巴结转移伴有胃外器官转移和仅有淋巴结转移均与无淋巴结转移的胃癌组织中OPN的阳性表达率有明显差异 ,分别为 χ2 =8 396 ,P =0 0 0 4 ;χ2 =6 4 93,P =0 0 11。结论 :OPN与胃癌的侵袭转移密切相关 。 Objective: To investigate the relationship of the osteopontin expression with the invasion and metastasis of gastric cancer. Methods: The expression of OPN was examined in 12 cases' non-cancer gastric tissues and 72 cases' gastric cancer tissues by using immunohistochemical method. Results: (1) The positive rates of OPN expression were 0?43.3%(13/30)?76.92%(20/26)and 87.5%(14/16) in 12 cases' non-cancer gastric tissues,30 cases' gastric cancer tissues without lymph nodes metastasis, 26 cases' gastric cancer tissues with lymph nodes metastasis and 16 cases' gastric cancer tissue with lymph nodes and other organs remote metastasis, respectively. (2) The positive rates of OPN expression in the gastric cancer tissue with lymph nodes and other organs metastasis or with lymph nodes metastasis only were entirely higher than those without lymph node metastasis, differences were respectively significent(χ 2=8.396, P=0.004; χ 2=6.493, P=0.011).Conclusions: OPN expression is closely related to the invasion and metastasis of gastric cancer , its molecular mechanism needs studying further.
作者 张东涛 杨力 郭新宁 胡建国 张飞雄 翟惠虹 赵小红 樊代明
机构地区 宁夏医学院 宁夏医学院附属医院消化内科 第四军医大学西京医院消化病研究所
出处 《宁夏医学院学报》 2004年第2期82-84,F003,共4页 Journal of Ningxia Medical College
基金 国家自然科学基金资助项目 ( 3 0 160 0 3 3 )
关键词 胃癌 侵袭转移 骨桥蛋白 gastric cancer invasion and metastasis osteopontin
分类号 R735.2 [医药卫生—肿瘤] R730.21 [医药卫生—肿瘤]
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参考文献12

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宁夏医学院学报
2004年 第2期

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