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急性白血病患者多药耐药基因MDR1的表达及临床意义的研究 被引量：2

The expression and clinical significance of MDR1 mRNA in acute leukemia
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摘要 目的　探讨急性白血病 (AL)患者多药耐药基因MDR1的表达和化疗敏感性的关系。方法　应用实时荧光定量RT PCR技术测定 4 5例初治AL患者MDR1水平的表达。结果　耐药组MDR1阳性表达 (5 6 .5 2 % )明显高于敏感组 (1 3.6 4 % ) ,P <0 .0 1 ,两组差异显著 ,有统计学意义。结论　MDR1基因表达是AL临床耐药的因素之一。 Objetive To investigate the relationship between the expression of MDR1 and the clinical resistance in acute leukemias.Methods MDR1 mRNA was detected by RT PCR in 45 AL samples.Results The expressions of MDR1 mRNA was significantly higher in resistance group(56.52%) than in sensitivity group(13.64%)( P <0.01).Conclusion The expression of MDR1 mRNA is the factor of clinical resistance in acute leukemias.
作者 陈伟 杨沛 邓少丽 胡永发
机构地区 第三军医大学大坪医院野战外科研究所检验科
出处 《重庆医学》 CAS CSCD 2004年第6期878-879,共2页 Chongqing medicine
关键词 急性白血病 多药耐药基因 化疗敏感性 acute leukemia multidrug resistance gene clinical significance
分类号 R733.7 [医药卫生—肿瘤]
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参考文献9

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同被引文献21

  • 1卜俊国,袁亚维,陈俊.X射线照射后鼻咽癌细胞多药耐药基因的表达[J].第一军医大学学报,2004,24(6):646-649. 被引量：23
  • 2冯丹,刘云鹏.GST-π与恶性肿瘤多药耐药的研究进展[J].肿瘤防治杂志,2004,11(6):663-665. 被引量：14
  • 3张俊,计骏,纪玉宝,袁菲,刘炳亚,朱正纲,林言箴.化疗药物杀伤原代胃癌细胞效应与P-糖蛋白和GST-π表达的关系[J].癌症,2005,24(4):432-437. 被引量：2
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重庆医学
2004年 第6期

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