脑热清口服液治疗颅脑手术后发热的临床疗效研究

Research on the Clinical Efficacy of Naoreqing Oral Solution in the Treatment of Postoperative Fever in Craniocerebral Operations

目的 观察脑热清口服液治疗颅脑术后发热的临床疗效。方法 按神经外科自然病区随机分成脑热清组 (简称治疗组 ,86例 ) ,脑热清结合西药组 (简称结合组 ,2 76例 )和西药组 (89例 )。治疗组给予脑热清口服液 5 0mL ,每天 2～ 3次口服 ,西药组给予西药常规治疗 ,结合组在西药基础上给予脑热清 ,方法剂量同治疗组 ,连续用药 7d。比较 3组的退热度数、治愈率、治愈加显效率、总有效率 ;比较治疗组和结合组组内对感染和非感染性发热的退热度数和疗效 ,对脑膜瘤和胶质瘤的退热度数和疗效。结果 治疗组和结合组 ,其退热幅度明显大于西药组 ,治愈率、治愈加显效率和总有效率均明显高于西药组 ,治疗组和结合组间无显著性差异。脑热清对颅内感染和非感染性发热均有较好的退热作用 ,其对两者的退热度数、治愈率、治愈加显效率和总有效率均无显著性差异 ;结合组对感染性发热退热幅度大 ,其余也无显著性差异。治疗组和结合组对脑膜瘤和胶质瘤术后发热均有较好的退热作用 ,退热度数、治愈率、治愈加显效率和总有效率均无显著性差异。结论 脑热清口服液对术后发热有显著的退热作用 ,对感染和非感染性发热均有效 ,退热作用与脑瘤性质无关。

Objective To observe the clinical efficacy of Naoreqing Oral Solution (NOS) in the treatment of postoperative fever in craniocerebral operations. Methods Patients from the neurosurgical diseases section of the hospital were randomly divided into the NOS group (86 cases), the NOS plus western-style drug group (the NOS-WD group, 276 cases), and the western-style drug group (the WD group, 89 cases). The NOS group was given NOS at a dose of 50 ml/2 or 3 times/day; the WD group, the routine western-style drugs; and the NOS-WD group, routinewestern-style drugs and NOS; all groups were administered for the same doses for 7 days successively. The degrees of temperature lowered, cure rate, cure plus effectual rate and the total effective rate were compared among the three groups; the degrees of temperature lowered and the effective rates for both infective fever and noninfective fever were compared between the NOS group and NOS-WD group; and the degrees of temperature lowered and the effective rates for meningoma and glioma were also compared between the NOS group and NOS-WD group. Results The extent of the temperature lowered in the NOS group and the NOS-WD group was much greater than that in the WD group; the cure rate, cure plus effectual rate and the total effective rate in the NOS group and the NOS-WD group were much higher than those in the WD group; and as far as these criteria were concerned, there was no difference between the NOS group and NOS-WD group. NOS manifested a very good antipyretic effect on both intracranial infective fever and noninfective fever, without obvious difference between the treatments of the two types of fever concerning the degrees of temperature lowered, cure rate, cure plus effectual rate and the total effective rate; and NOS-WD, except for a larger extent of temperature decrease for intracranial infective fever, showed no obvious difference between the treatments of the two types of fever concerning the above-mentioned criteria. Both NOS and NOS-WD showed a good antipyretic effect on the postoperative fever due to the operations of meningoma and glioma, without obvious difference between the treatments of the two types of tumor concerning the degrees of temperature lowered, cure rate, cure plus effectual rate and the total effective rate.Conclusion NOS possesses a marked antipyretic effect on postoperative fever, being effective for both infective and noninfective fever, and its antipyretic effect is not related with the properties of the cerebral tumors.