柳氮磺吡啶-β-环糊精包合物的研制

Study on sulfasalazine-β-CD complex

目的 :制备柳氮磺吡啶 β 环糊精包合物以提高柳氮磺吡啶的溶解度。 方法 :采用研磨法制备柳氮磺吡啶 β 环糊精包合物。结果 :经显微镜法鉴定 ,表明已形成包合物。包合后 ,其水中溶解度由包合前 0 .0 0 2 2mg·L-1提高到 0 .10 3mg·L-1,溶出速度 (T50 )提前 4min。结论 :柳氮磺吡啶 β 环糊精包合物可明显提高其溶解度 。

OBJECTIVE To prepare the inclusion complex of su lfasalazine-β-CD for improving solubility. METHODS The sulfasalazine-β-CD was prepared by the method of trituration. RESULTS Microscopical examination comfirmed the formation of th e complex, its solubility in water was 45.66 times the value of that before inclusion (from 0.0022 mg·L -1 to 0.103 mg·L -1), the dis solution (T 50) being put forward by 4 minutes. CONCLUSIONS SASP-β-CD complex can greatly increase its solub ility and dissolution.