外周血VEGF表达水平与舌癌颈淋巴结转移关系的临床研究

The level of VEGF in serum can reflect the metastasis of tongue cancer

目的 :探讨外周血VEGF表达水平与舌癌转移之间的关系以及临床意义。方法 :对舌癌患者外周血VEGF的表达水平进行ELISA检测 ,并对患者术后所有颈部淋巴结进行HE染色。结果 :转移组患者血清VEGF浓度为 ( 5 0 8.2 8± 14 .193 3 ) pg/ml ,无转移组患者血清VEGF浓度为 ( 13 0 .49± 6.2 5 41) pg/ml ,二者存在显著差异 (P <0 .0 1)。转移组患者术后血清VEGF浓度显著下降 ,为 ( 14 1.79± 5 .2 2 41) pg/ml,与术前存在显著差异 (P <0 .0 1)。结论 :舌癌患者血清VEGF浓度与颈淋巴结转移的发生有显著相关性 。

Objective: To investigate the relationship between the VEGF level in serum and the metastasis of tongue cancer. Methods: Every lymph node in neck with HE stain after operation was examined and the level of vascular endothelial growth factor (VEGF) in the serum was measured by means of enzyme linked immunosorbent assay in 50 cases of tongue cancer. Serum VEGF level of 20 heathy subjects was used as the control. Results: The serum level of VEGF in the healthy controls was (85.12±2.15) pg/ml, that in the metastasis group (31 cases) (508.28±14.19) pg/ml, while in the non-metastasis group (130.49±6.25) pg/ml(P<0.01). After operation the serum level of VEGF in the metastasis group decreased to(141.79±5.22) pg/ml( P<0.01). Conclusion: The level of VEGF in serum can reflect metastasis in the patients with tongue cancer.