研究种植义齿骨界面改建的beagle犬动物模型的建立

Establishment of the Beagle dog model for the study of the influence of masticatory force on the bone remodeling of implant-bone interface.

目的 :建立beagle犬动物摸型 ,用以研究在体内情况下埋植型与非埋植型种植义齿受力后其骨界面改建的机制。方法 :选用纯系动物beagle犬 8只 ,采用固定金属全冠行埋植型与非埋植型种植义齿修复 ,建立模拟正常咀嚼状态的动物模型。结果 :beagle犬埋植型与非埋植型种植义齿制作顺利。种植义齿修复后所有实验犬均咀嚼颗粒状硬质饲料 ,观察发现修复前后实验犬的咀嚼方式无明显改变。负载 12周均未发现明显的咬合创伤 ,其种植体固定无松动。结论 :所建动物模型能达到较好地模拟正常咀嚼状态的目的 ,动物模型是有效。

Objective: To establish a Beagle dog model for the study of the mechanism of implant-bone interface remodeling following the restoration of submerged and nonsubmerged implant denture. Methods: 8 adult purebred beagle dogs were used to build the animal model. Fixed metal full crown was used to carry out submerged and nonsubmerged implant denture in the dogs to mimic the normal chewing status in animal models. Results: The submerged and nonsubmerged implant dentures were made successfully. After the implant denture restoration, all experimental dogs were fed with granular horniness forage to guarantee enough biting stimulation. The chewing fashion of experimental dogs was not changed obviously during the experiment process. Although the horniness forage may result in fairly bigger bite force, no visble biting hurt was found 12 weeks after loading and the fixed implant dentures were all preserved. Conclusion: The beagle dog model can preferably mimic the normal chewing fashion and the models are both availability and credibility.