摘要
目的探讨肿瘤坏死因子-α(TNF-α)细胞间粘附分子-1(ICAM-1)和血管细胞粘附分子(VCAM-1)在慢性排斥移植肾组织中的表达及其意义。方法采用免疫组化技术对30例慢性排斥移植肾活检组织中TNF-α、ICAM-1和VCAM-1表达进行检测。12例正常肾脏组织作为对照。结果在发生慢性排斥的移植肾组织中,大多数病例有活动性间质及血管周围淋巴细胞浸润和小管局部炎症,肾小球、肾小管及间质浸润细胞TNF-α、ICAM-1和VCAM-1表达程度和分布普遍增强,但主要见于间质浸润细胞、肾小管损伤部位上皮细胞、炎症区域管周毛细血管和微小动脉内皮细胞,与正常对照有明显差异。结论细胞免疫可能在慢性排斥发病中起作用,细胞因子和粘附分子则是一过程中的重要介质。
Objective: To study expression and significance of tumor necrosis factor alpha (TNF-α), intercellular adhesion molecule (ICAM-1), vascular cellular adhesion molecule-1 (VCAM-1) in the renal allograft of chronic rejection. Methods: 30 biopsy specimens from renal transplant recipients with chronic rejection were analyzed by immunohistochemical technique, and 12 specimens of normal renal tissue were taken as controls. Results: Most of the renal allografts of chronic rejection had interstitial and perivascular lymphocytes infiltration and local tubular inflammation. A markedly increased expression of TNF-α, ICAM-1, VCAM-1 in the glomerulus, tubular epithelial cells and lymphocytes, interstitial infiltrating lymphocytes, especially in the peritubular capillaries and microvascular endothelium was found. Conclusions: The cellular immune may play an essential role in the pathogenesis of allograft of chronic rejection and cytokines and adhesion molecules are the important mediators of the event.
出处
《中国现代医学杂志》
CAS
CSCD
2004年第10期59-62,共4页
China Journal of Modern Medicine